Asssignees: Perlegen Sciences, Inc., Mountain View, CA (US); St. Jude Children's Research Hospital, Memphis, TN

The present invention provides methods and compositions for the treatment of DNA damage related disorders. One embodiment is a method for the inhibition of Side effects asSociated with chemotherapeutic and radiotherapeutic agents using chloroquine compounds. Another embodiment is a method for treatment and/or prevention of lethal or Sub-lethal radiation toxicities associated with terrorist acts or Wa.